Tucaresol: A Unique Oral Candidate Drug Ideally Accessible for Treatment of Covid-19 Disease

Abstract

The SARS-CoV-2 pandemic has significantly impacted world health and economic
status. In response, much work has been undertaken to provide effective, safe
vaccines, antibodies and antiviral drugs with which to address this pandemic.
Treatment of a pandemic population presents multiple challenges in addition to
the primary issue of drug efficacy and safety, such as large scale drug manufacture
and distribution, drug stability, oral dosing and pharmacoeconomic
considerations. Ideally, these factors must be addressed if new candidate drugs
are to be advanced for treatment of large (pandemic) populations. Subsequently,
new antivirals have reached the market but choices are few. According to the
NIH Covid Treatment Guidelines, only three small molecule antiviral drugs are
available to treat Covid-19 disease. As such, a significant part of the research
towards discovery of new antiviral drugs has focused on screening and evaluation
of ‘repurposed drugs’ or previously approved or clinical stage drugs. Yet, in
spite of this increased research activity, one promising clinical stage candidate
drug has received little attention regarding its potential as a monotherapy or
component of combination therapy for treatment of Covid-19 disease. Tucaresol,
with documented human safety and pharmacokinetic data, is an orally active,
stable, small molecule amenable to large scale manufacture by a proprietary
two-step synthesis developed by us. Tucaresol functions as a host-targeted
antiviral by selective protection/reconstitution of CD4+ T helper cells as
demonstrated in HIV patients and SIV macaques. In view of similarities between
HIV and SARS-CoV-2, especially with respect to host CD4+ T helper cells, and
the suitability of Tucaresol for facile treatment of pandemic populations,
Tucaresol is presented herein for treatment of mild-to-moderate Covid-19
patients but may also be useful for treatment of advanced disease accompanied
by lymphopenia.